People living with serious illness(es) typically experience multiple symptoms throughout their disease trajectory. Nurses need to be knowledgeable about evidence-based assessment and symptom management for common physical, psychological, and spiritual symptoms. Interprofessional teams must work collaboratively with the patient and family (of origin and chosen) when managing symptoms to enhance quality of life and reduce unnecessary suffering. This module will provide you with an overview of common symptoms experienced by patients with serious illness(es) and will emphasize your important role in assessing and managing them. The goal of this module is to provide undergraduate and new graduate nurses with knowledge of symptom management for patients with serious illness(es).