Red blood cells can be transfused for cases of hemorrhage, severe anemia, and certain percentages of blood loss to help improve the delivery of oxygen to tissues. Guidelines have become more restrictive and blood is often reserved until hemoglobin (Hgb) is less than 7 mg/dL or symptoms are present (Lotternam & Sharma, 2021). It can also be used for acute sickle cell crisis as well as a reversal agent for anticoagulation. Careful administration of all blood products requires adherence to specific guidelines to ensure safety and optimal, therapeutic outcomes.