Drug Interactions and Toxicity with Acetaminophen and Nonsteroidal Anti-Inflammatory Drugs
Certificates
New York Physical Therapy
The New York State Education Department's State Board for Physical Therapy has recognized Relias Learning, LLC as an approved provider of physical therapy and physical therapy assistant continuing education. This activity is approved for 1.50 contact hours.
Texas Physical Therapy Association
This activity is provided by The Texas Board of Physical Therapy Examiners Accredited Provider #1902008TX and meets continuing competence requirements for physical therapist and physical therapist assistant licensure renewal in Texas.
This course is not approved as meeting the ethics and professional requirements for Texas physical therapists or physical therapist assistants.
The assignment of Texas PT CCUs does not imply endorsement of specific course content, products, or clinical procedures by TPTA or TBPTE. This activity is approved for 1.50 contact hours.
Oklahoma Board of Medical Licensure and Supervision
Oklahoma Physical Therapy Advisory Committee has approved this course under Category B. Approval # 202111166. This activity is approved for 1.50 contact hours.
Minnesota State Board of Physical Therapy
This course is approved by the Minnesota Board of Physical Therapy for 1.50 Category 1 credits and offered to PTs and PTAs for CEUs.
Nevada State Board of Physical Therapy Examiners
This course has been approved by the Nevada State Board of Physical Therapy Examiners. This activity is approved for 1.50 contact hours.
Course Details
Describe the process of prostaglandin production from the arachidonic acid cycle in the cell.
Briefly discuss the supportive and inflammatory effects of prostaglandins in the body.
Discuss the operant mechanism in the development of hepatotoxicity due to excessive acetaminophen ingestion.
List the symptoms of acute acetaminophen overdose and describe the appropriate treatment modalities.
Describe the differences between nonselective and selective COX inhibitor NSAIDs.
Describe the mechanism by which aspirin decreases the ability of platelets to aggregate for clot formation.
List the symptoms of aspirin overdose and describe the required treatment.
Outline the mechanism by which aspirin may produce increased bronchospasm in an individual with asthma.
Describe three types of pharmacokinetic interactions that can change the clinical effectiveness or increase the risk of toxicity of NSAIDs.
Describe the NSAID induced changes that ultimately may be responsible for the development of nephrotoxicity and/or gastric bleeding.
Outline:
NSAID use
The Eicosinoids
Prostaglandin Activities
Medical Uses
Physiological Basis for Pharmacological Activity
NSAID Activity
Adverse Effects
Tylenol
Mechanisms in Overdose
Symptops in Tylenol Overdose
Asperin
Dosage in Overdose
Mechnaism of Overdose
Symptoms in ASA Overdose
Aspirin and Asthma
Asthma and ASA Intolerance
Asthma Effect
Common Members of the NSAID Families
What Did Research from 1999 to 2004 Demonstrate?
Potential Interaction Types
Pharmacokinetic interactions
Decreased Absorption of NSAIDs
Protein Binding
Asperin Protein Binding
Digoxin protein binding
Hepatic P450 Interactions
CYP2C9
Fluconazole
Rifampicin
Warfarin and CYP2C9
Warfarin Pharmacogenomics
Allele
Warfarin
CYP2D6
Coversion of Prodrug to Active Drug
CYP3A4
Renal Elimination
Pharmacodynamic
Inhibition of Renal Prostaglandins
Increased Risk of Nephrotoxicity
Increased GI Bleed
NSAID Summary
References
A Professor Emeritus in the Department of Nursing at California State University in Long Beach, CA, Dr. Callahan received her nursing education at Rockingham Community College, Wentworth, North Carolina, and her anesthesia education at the Anesthesia Program for Nurses at North Carolina Baptist Hospital, Bowman Gray School of Medicine, Winston Salem, North Carolina. The recipient of a BS in Biology from Guilford College in Greensboro, North Carolina, a MA in Education, and a MS in Nursing from California State University in Long Beach, California, she received her PhD in Educational Research and Evaluation from Florida State University, Tallahassee, Florida in 1994. In the summer of 2003, Dr .Callahan was a fellow in the Genetics Institute of the National Institute of Nursing Research/National Institutes of Health, Bethesda, Maryland. Dr. Callahan has a broad base of practice experience as an educator, clinician, administrator, and consultant. She has written numerous publications and is widely known as a continuing education lecturer in the field of anesthesia, pain management, and the sciences. She is a Past-President of the American Association of Nurse Anesthetists. Dr. Callahan remains clinically active, and enjoys teaching both in the college classroom as well as her nationally presented seminars. Disclosure: Linda L. Callahan, CRNA, PhD has declared that no conflict of interest, Relevant Financial Relationship or Relevant Non-Financial Relationship exists.
The target audience for this course is: Entry level Physicians; Intermediate level Physical Therapists; Nurses; in the following settings: All Healthcare Settings.
F755, F757, F759, F760
Asynchronous/Online Distance Learning; please see certificate details for specifics on delivery format.
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All courses offered by Relias, LLC are developed from a foundation of diversity, inclusiveness, and a multicultural perspective. Knowledge, values and awareness related to cultural competency are infused throughout the course content.
Reference herein to any specific commercial product, process, or service by trade name, trademark, service mark, manufacturer or otherwise does not constitute or imply any endorsement, recommendation, or favoring of, or affiliation with, Relias, LLC.
All characteristics and organizations referenced in the following training are fictional. Any resemblance to any actual organizations or persons living or dead, is purely coincidental.
To earn continuing education credit for this course you must achieve a passing score of 80% on the post-test and complete the course evaluation.
If you require special accommodations to complete this module, please contact Relias Customer Support here.
