Drug Interactions and Toxicity with Acetaminophen and Nonsteroidal Anti-Inflammatory Drugs

Drug Interactions and Toxicity with Acetaminophen and Nonsteroidal Anti-Inflammatory Drugs 

Nurses providing care to both inpatient and outpatient populations currently face greater complexity in the drug regimens that patients present with than ever before. The role of the clinician includes recognition of risk, as well as identification of interactions that are manifest. This course examines specific groups of drugs commonly encountered by clinicians. Emphasis will be placed on recognition of the potential for untoward interactions, including operant mechanisms, as well as on the identification of strategies to ensure patient safety. Members of this presentation's planning committee do not have a financial relationship with a Commercial Interest Organization that could create a conflict of interest while planning, implementing or evaluating the content of this presentation.


Hours: 1.50


Certificates provided by accrediting body (5 Match)

New York Physical Therapy


The New York State Education Department's State Board for Physical Therapy has recognized Relias Learning, LLC as an approved provider of physical therapy and physical therapy assistant continuing education. This activity is approved for 1.50 contact hours.

Texas Physical Therapy Association


This activity is provided by The Texas Board of Physical Therapy Examiners Accredited Provider #1902008TX and meets continuing competence requirements for physical therapist and physical therapist assistant licensure renewal in Texas.
This course is not approved as meeting the ethics and professional requirements for Texas physical therapists or physical therapist assistants.
The assignment of Texas PT CCUs does not imply endorsement of specific course content, products, or clinical procedures by TPTA or TBPTE. This activity is approved for 1.50 contact hours.

Oklahoma Board of Medical Licensure and Supervision


Oklahoma Physical Therapy Advisory Committee has approved this course under Category B. Approval # 202111166. This activity is approved for 1.50 contact hours.

Minnesota State Board of Physical Therapy


This course is approved by the Minnesota Board of Physical Therapy for 1.50 Category 1 credits and offered to PTs and PTAs for CEUs.

Nevada State Board of Physical Therapy Examiners


This course has been approved by the Nevada State Board of Physical Therapy Examiners. This activity is approved for 1.50 contact hours.

Course Details

Course Code: REL-RT-0-RN251C
Hours: 1.5
Type: Online Course
Content Expiration Date: 1/31/2021
Learning Objectives:
Describe the process of prostaglandin production from the arachidonic acid cycle in the cell.
Briefly discuss the supportive and inflammatory effects of prostaglandins in the body.
Discuss the operant mechanism in the development of hepatotoxicity due to excessive acetaminophen ingestion.
List the symptoms of acute acetaminophen overdose and describe the appropriate treatment modalities.
Describe the differences between nonselective and selective COX inhibitor NSAIDs.
Describe the mechanism by which aspirin decreases the ability of platelets to aggregate for clot formation.
List the symptoms of aspirin overdose and describe the required treatment.
Outline the mechanism by which aspirin may produce increased bronchospasm in an individual with asthma.
Describe three types of pharmacokinetic interactions that can change the clinical effectiveness or increase the risk of toxicity of NSAIDs.
Describe the NSAID induced changes that ultimately may be responsible for the development of nephrotoxicity and/or gastric bleeding.

The Eicosinoids
Prostaglandin Activities
Medical Uses
Physiological Basis for Pharmacological Activity
NSAID Activity
Adverse Effects
Mechanisms in Overdose
Symptops in Tylenol Overdose
Dosage in Overdose
Mechnaism of Overdose
Symptoms in ASA Overdose
Aspirin and Asthma
Asthma and ASA Intolerance
Asthma Effect
Common Members of the NSAID Families
What Did Research from 1999 to 2004 Demonstrate?
Potential Interaction Types
Pharmacokinetic interactions
Decreased Absorption of NSAIDs
Protein Binding
Asperin Protein Binding
Digoxin protein binding
Hepatic P450 Interactions
Warfarin and CYP2C9
Warfarin Pharmacogenomics
Coversion of Prodrug to Active Drug
Renal Elimination
Inhibition of Renal Prostaglandins
Increased Risk of Nephrotoxicity
Increased GI Bleed
NSAID Summary

Instructor: Linda L. Callahan, CRNA, PhD
A Professor Emeritus in the Department of Nursing at California State University in Long Beach, CA, Dr. Callahan received her nursing education at Rockingham Community College, Wentworth, North Carolina, and her anesthesia education at the Anesthesia Program for Nurses at North Carolina Baptist Hospital, Bowman Gray School of Medicine, Winston Salem, North Carolina. The recipient of a BS in Biology from Guilford College in Greensboro, North Carolina, a MA in Education, and a MS in Nursing from California State University in Long Beach, California, she received her PhD in Educational Research and Evaluation from Florida State University, Tallahassee, Florida in 1994. In the summer of 2003, Dr .Callahan was a fellow in the Genetics Institute of the National Institute of Nursing Research/National Institutes of Health, Bethesda, Maryland. Dr. Callahan has a broad base of practice experience as an educator, clinician, administrator, and consultant. She has written numerous publications and is widely known as a continuing education lecturer in the field of anesthesia, pain management, and the sciences. She is a Past-President of the American Association of Nurse Anesthetists. Dr. Callahan remains clinically active, and enjoys teaching both in the college classroom as well as her nationally presented seminars. Disclosure: Linda L. Callahan, CRNA, PhD has declared that no conflict of interest, Relevant Financial Relationship or Relevant Non-Financial Relationship exists.
Target Audience:
The target audience for this course is: Entry level Physicians; Intermediate level Physical Therapists; Nurses; in the following settings: All Healthcare Settings.
F Tags:
F755, F757, F759, F760
Relias will be transparent in disclosing if any commercial support, sponsorship or co-providership is present prior to the learner completing the course.
Course Delivery Method and Format
Asynchronous/Online Distance Learning; please see certificate details for specifics on delivery format.
Relias has a grievance policy in place to facilitate reports of dissatisfaction. Relias will make every effort to resolve each grievance in a mutually satisfactory manner. In order to report a complaint or grievance please contact Relias.
If you require special accommodations to complete this module, please contact Relias Support by completing the web form (https://www.relias.com/help) or by using the chat functionality.
All courses offered by Relias, LLC are developed from a foundation of diversity, inclusiveness, and a multicultural perspective. Knowledge, values and awareness related to cultural competency are infused throughout the course content.
Reference herein to any specific commercial product, process, or service by trade name, trademark, service mark, manufacturer or otherwise does not constitute or imply any endorsement, recommendation, or favoring of, or affiliation with, Relias, LLC.
All characteristics and organizations referenced in the following training are fictional. Any resemblance to any actual organizations or persons living or dead, is purely coincidental.
To earn continuing education credit for this course you must achieve a passing score of 80% on the post-test and complete the course evaluation.
If you require special accommodations to complete this module, please contact Relias Customer Support here.