Despite the multiple advantages of digital imaging technology, the inherent disadvantages of mammography imaging have not disappeared. In mammography imaging, cancer is visualized as a white area within the background density of the breast. The sensitivity of the system will, therefore, depend on breast density, patient age, or patient hormone status. Mammography also tends to understate the multifocality of a lesion, and inadequate compression and poor positioning will affect interpretation. Therefore, 2-D imaging is not 100% effective as an imaging tool; it is limited by tissue superimposition. These overlapping tissues can mask or mimic tumors, leading to false-negative or false-positive reports. To minimize the disadvantages of 2-D imaging, the concept of 3-D imaging, or digital breast tomosynthesis, was incorporated in breast screening and diagnostic workups.